The number of grapes are in a bottle of red wine? A bottle of white wine usually consists of 25 ounces of white wine, which is equivalent to 750 mL. how to make wine from grapes at home step by step serving of wine is 5 ounces, which implies that each bottle includes about 5 portions. If you were to divide a bottle of red wine into 5 portions, you would end up with about 150 grapes.